Editorial

• The burden and the challenge of treatment-resistant depression - Charalampos Touloumis - (pages 11 - 14) - (https://doi.org/10.22365/jpsych.2021.046)

Special Articles

• Treatment resistant depression: Challenges and therapeutic choices - Charalampos Touloumis - (pages 15 - 31) - (https://doi.org/10.22365/jpsych.2021.047)
• Clinical characteristics and treatment of treatment-resistant bipolar depression - Grigorios N. Karakatsoulis, Eva-Maria Tsapakis, Konstantinos N. Fountoulakis - (pages 32 - 43) - (https://doi.org/10.22365/jpsych.2021.048)
• Peripheral prognostic biomarkers of response in treatment-resistant depression - Agorastos Agorastos, Theano Gkesoglou, Anastasios Kleidonopoulos, Vasilios P. Bozikas - (pages 44 - 54) - (https://doi.org/10.22365/jpsych.2021.049)
• Pharmacology of ketamine and esketamine as rapid-acting antidepressants - Pavlina Pavlidi, Anastasia Megalokonomou, Adrian Sofron, Nikolaos Kokras, Christina Dalla - (pages 55 - 63) - (https://doi.org/10.22365/jpsych.2021.050)
• Ketamine infusion therapy in treatment-resistant depression - Τheodosios Ε. Christodoulakis - (pages 64 - 69) - (https://doi.org/10.22365/jpsych.2021.051)
• The role of ketamine in the treatment of treatment-resistant bipolar depression - Grigorios N. Karakatsoulis, Eva-Maria Tsapakis, Konstantinos N. Fountoulakis - (pages 70 - 81) - (https://doi.org/10.22365/jpsych.2021.052)
• Electroconvulsive therapy in treatment resistant depression: What is new? - Styliani C. Kaliora - (pages 82 - 89) - (https://doi.org/10.22365/jpsych.2021.053)
• Advances in transcranial magnetic stimulation (TMS) and its applications in resistant depression - Theodoros Koutsomitros, Olympia Evagorou, Teresa Schuhmann, Antonis Zamar, Alexander T. Sack - (pages 90 - 98) - (https://doi.org/10.22365/jpsych.2021.054)

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